The latest advances in lower limb ischemia treatment focus on improving blood flow and reducing symptoms. New endovascular techniques, such as drug-coated balloons and stents, offer less invasive alternatives to traditional surgery. These treatments help open blocked arteries, enhancing circulation. Additionally, stem cell therapy is being explored for its potential to regenerate damaged tissues and improve limb function. Pharmacological treatments, including anti-inflammatory drugs and platelet inhibitors, also play a significant role in reducing complications. Advanced imaging technologies help clinicians precisely target areas needing intervention, ensuring more effective and personalized lower limb ischemia treatment for patients.